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Around eighty% of TTP is induced by deficient action of ADAMTS13. ADAMTS13 deficiency can be constitutive, on account of biallelic ADAMTS13 pathogenic variants; or acquired, because of an inhibitory antibody. Analysis of ADAMTS13 activity is done using exams based on the potential of the protease to cleave normal VWF multimers in vitro (e.Due to co